#267: Fasting, Autophagy & mTOR Inhibition w/ Peter Attia, MD

Fasting is the single most potent tool within our toolbox of nutrition

If the purpose of your fast is caloric restriction and weight loss, I don't see how coffee is breaking that

From the animal data, the only two interventions that really seemed to offer longevity over this billion-year hurdle of evolution... are rapamycin and some degree of fasting

I try to lift heavy as possible during a fast and I do so every day as a way to stimulate mTOR in the muscle [and prevent muscle loss]

If there was one disease state that seems to benefit more from a ketogenic diet than any of the others it’s type 2 diabetes

The definition of what breaks a fast is as subjective as the definition of, 'What is sex?'

I would argue fasting is the single most important tool for treating metabolic disease

Autophagy probably starts around day 3 of a prolonged water-only fast

I'm pretty confident that intravenous NAD does not make any sense... I think intravenous NAD is somewhere between useless and harmful.

I think oral nicotinamide riboside (NR) is somewhere between useless and maybe potentially beneficial

Airplanes, believe it or not, given how frequently I fly, tend to be where I do my best writing

It seems to me it should be easier to activate sirtuins [which resveratrol does] than trying to get NAD into mitochondria. That seems to be a really hard problem.