Dr. Peter Attia: Supplements for Longevity & Their Efficacy

It's just so hard for me to imagine that any supplement or any drug, including rapamycin, which I think is the most most promising geroprotective protective drug we have, I just can't imagine that those things even compare to what good sleep, good exercise, and good nutrition do for your energy levels and vitality.

Everything we have talked about on this podcast today, whether it be NR, NAD, NMN, theracumin, magnesium, this supplement, that supplement, all of that stuff, while potentially mattering, I would put in the category of was the Titanic serving lobster or steak?

For you and I to live longer, we basically have to delay the onset of cardiovascular disease, cerebrovascular disease, cancer, neurodegenerative diseases, dementing diseases, and metabolic diseases. We have to delay the onset of those things. The longer we delay the onset, the longer we will live, full-stop.

We believe that when sirtuins are activated, they're improving mitochondrial biogenesis, they are increasing DNA repair... and also reducing sass, so the soluble products of senescent cells.

I think the whole NMN and NR debate is irrelevant. I think it's just a commercial debate. I think it's literally just posturing about how can I carve out a different market? I don't think there's a scientific reason to favor one over the other.

I think it would be a very safe bet that severe caloric restriction will absolutely reduce the risk of most chronic diseases.

The ITP has tested probably north of 50 molecules, meaning it has done the same experiment for 50 different molecules, and very few have extended lifespan, and a notable failure is NR.

You have to eat, you have to sleep, you have to move. You just have a choice, and do you want to do those things correctly or not correctly? Or do you want to do those things in a manner that promotes health or erodes health?

If you want to live longer... that turns out to be mathematically equivalent in the modern society to delaying the onset of chronic disease.

Resveratrol activates sirtuins. Sirtuin activation is important because... it improves mitochondrial biogenesis, it suppresses senescent cells, and it enhances DNA repair.

NAD levels are declining with age in most tissues. It appears most prevalent in the skin of all places.