AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory

I take 400-800 milligrams of grape seed extract, usually with a meal—it's just part of my standard supplementation stack—every single day. But I do that mainly for its effects on vascular function and blood flow and a few other effects that grape seed extract has been related to.

There is no supplement or drug for increasing longevity that even comes close to the known improvements in health metrics that relate to longevity that come from getting quality sleep and especially from getting sufficient amounts of quality exercise.

I do indeed take an NR supplement every day. I take 500 mg of NR. I also, and have separately taken, an NMN supplement. I take sublingual NMN. So, I'll take anywhere from 1-2 grams of NMN as a sublingual powder.

I think that most people understand that while indeed resveratrol might have some positive effects on the functioning of our cells that there is very little, if any, direct evidence that resveratrol can increase lifespan.

When I take NR and NMN at the dosages I talked about a little bit earlier, it gives me a lot of sustained mental and physical energy throughout the day.

I've taken anywhere from 500 to 1000 mg of NAD by infusion. I did that at times when I was feeling particularly run down post-illness. And I did indeed find that after the NAD infusion was complete, I felt much much better.

I'll take my NR and NMN sometime usually within about an hour or two of waking up and typically at least 30 minutes to 2 hours before my first meal, which for me usually arrives around 11 AM.

I'll just be very direct and say I do not take metformin. And I also don't take what some people call the poor man's version of metformin, which is berberine. Berberine gives me brutal headaches. Berberine lowers blood glucose—that's why I think it's giving me brutal headaches.

At present, there isn't sufficient data to support taking metformin for increasing lifespan. So, that's why I don't take it. In the future, if more data come out and things change, but right now, I see no reason to take, metformin to increase my lifespan. So, I don't take metformin.

I don't take rapamycin. Why don't I take rapamycin? Well, I don't take rapamycin because, at least to my eye, the data at present don't justify that for sake of increasing lifespan.