I would say, at the moment, the flu is much more of a concern. The flu is a serious disease with high rates of complication. Last year, 80,000 people in the U.S. died from the flu, and that dwarfs anything that's going on at the moment with the coronavirus.

Ordinary masks are permeable by viruses. They don’t do anything to prevent you from getting infected. The only ones that reduce the possibility of inhaling or swallowing a virus are the N95 respirators."

The bottom quartile of risk for long-term chronic illness—people [must] maintain glucose levels between 70 and 110 or 120 mg/dL for 95% or 99% of the day ... I actually personally try to keep my blood sugar below 100 or 110 mg/dL including meals 24/7, and my average I shoot to keep at between 85 and 85 mg/dL.

Bright light exposure between the hours of about 10 PM and 4 AM, if it's chronic, if you do it more than every once in a while, triggers a suppression of dopamine that leads to deficits in learning, deficits in mood, and a whole host of other problems, including a connection to the pancreas that starts dis-regulating blood sugar.

This is the fastest way that I'm aware of that's anchored in real known biology to calm oneself down ... It's an inhale through the nose, and then it's another inhale at the top, and then a long exhale. That's the fastest way to slow your heart down and calm down.

When you pay very close attention to the way consciousness is in each moment, the sense of self drops away. There is no center to consciousness. There’s no subject interior to the body.

Dopamine, at least at modest levels, tends to increase the positivity of mood; it tends to make us more outward goal-directed; and it tends to place our body into a state of action ... Dopamine makes us want to move, it makes us motivated, and it makes us think about what's outside us that we want to pursue ... Serotonin tends to activate circuits in the brain and body that tend to make us feel rather placid, kind of blissed, and feel pretty good about what we've got in the present. It tends to restrict our goals toward things that are already in our immediate experience or possession.

If you are able to observe and hone your decision-making with even very small investments... that can transfer into better decision-making in other areas. We're all investors—of time, energy, capital. And you can choose to become better at those things, or you can remain blissfully unaware. But one way or another, you are making decisions about investment every day.

I think exercise is better than metformin for preventing type 2 diabetes, treating type 2 diabetes, and I also think it’s better than metformin at delaying aging… You’re better off exercising than taking a metformin pill.

Sulforaphane increases the excretion of harmful carcinogens like benzyne and acrolein, both of which are found in cigarette smoke and air pollution, by up to 60%.

Change doesn't happen due to complacency; it happens when there are these big bold moments that shock us into action.

As far as reading, these days, I definitely don't rush. If I'm rushing through a book, I should generally just drop the book—it's not good enough ... You should only be choosing books that you are sad to see end.

My great passion is product-market fit ... It's something that I find is the absolute key to success of a business, and I constantly try to figure out how to do a better job of finding it. And one of the things that's really clear to me is that if you don't find product-market fit immediately, you don't change the product; you change the market. You iterate on the market; you don't iterate on the product.

Meditation isn’t something you’re doing. It’s not actually a practice. When you’re actually practicing, you’re ceasing to do something that you always tend to do, and that thing is identify with each passing thought.

I'm a big proponent, based on 25 years of quality peer-reviewed work, of viewing bright light within the four to six hours after waking—but ideally within the first hour after waking.

Something like less than 10% of professional investors outperform the market over five years—and those are people who are doing it for a living every single day, so what makes an individual investor who's doing it with their spare time think they can outperform the market.

The experience of emptiness is to see that the sense of self has simply been an idea—it's been no more than that. But you have to experience it to get that. I think it's very hard to realize how pervasive the sense of self is until it's somehow gone.

Viewing light circa sunset adjusts the sensitivity of the cells in the eye such that it buffers you against some of the negative effects of light late at night. So, I call it sort of my Netflix vaccination—I can watch some late-night movie or TV or be on my screen a little bit later provided I got some sunlight right around sunset.

The sauna has been shown to mimic some of the effects of moderate-intensity aerobic exercise. A 25-minute sauna session was comparable to 25 minutes doing ~100 Watts on a stationary bike... During the activity, heart rate and blood pressure increased in both instances, but then immediately after, heart rate and blood pressure dropped below baseline levels.

There's no question that the sadness and the pain are coming. And the time to train to get better at that, to get more equanimous, to be more flexible, is now. It's very hard to get a strong meditation practice in hand when you really need it. The time to do that is when life is great...