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Dr. David Sinclair Intro (Episode Preview)
0:58 ·
Rewind Your Clock:
David Sinclair
, PhD Wants To 'Cure'
Aging
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The Rich Roll Podcast Intro
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, PhD Wants To 'Cure'
Aging
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Rich Introduces Dr. David Sinclair (Part I)
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, PhD Wants To 'Cure'
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AD: On Running
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, PhD Wants To 'Cure'
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AD: Squarespace
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, PhD Wants To 'Cure'
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AD: ZipRecruiter
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, PhD Wants To 'Cure'
Aging
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Rich Introduces Dr. David Sinclair (Part II)
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, PhD Wants To 'Cure'
Aging
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David Spent the Morning Working Out With Laird Hamilton & Using His Sauna
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, PhD Wants To 'Cure'
Aging
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How David Met Cold Therapy Guru Ray Cronise
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, PhD Wants To 'Cure'
Aging
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Ray Cronise & Julieanna Hever's New Book, 'The Healthspan Solution'
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, PhD Wants To 'Cure'
Aging
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Getting Your Body Out of Its Comfort Zone Fights Aging & Disease
1:22 ·
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, PhD Wants To 'Cure'
Aging
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Xenohormesis: Stressed Plants Contain Beneficial Polyphenolic Compounds
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, PhD Wants To 'Cure'
Aging
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Exercise & Fasting Activate a Genetic Pathway That Influences Longevity
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Sirtuins, 'The Pianist That Plays the Genetic Piano,' Get Distracted By DNA Damage
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NAD Is Fuel for Sirtuins; Resveratrol Is the Activator
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NAMPT, a Gene Activated By Heat, Produces NAD & Increases Sirtuin Function
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Mix Up Your Exercise, Sauna, & Cold Therapy Routine to Maximize the Hormetic Response
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Balancing Caloric Restriction & Intermittent Fasting to Maximize Hormesis
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, PhD Wants To 'Cure'
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David Sinclair's Intermittent Fasting Protocol & What Rich Has Learned from the Practice
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, PhD Wants To 'Cure'
Aging
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David Sinclair Is 50 and Doesn't Have a Single Gray Hair
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, PhD Wants To 'Cure'
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Horvath's Methylation Clock Is Central to the Information Theory of Aging
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, PhD Wants To 'Cure'
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What's David's Biological Age According to Horvath's Methylation Clock?
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David Is Trying to Make Horvath's Clock Biological Age Measurements More Accessible
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Lipolysis Byproducts, Olive Oil, & Resveratrol Activate Sirtuin Enzymes
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, PhD Wants To 'Cure'
Aging
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Consuming Resveratrol With a Fatty Solvent Increases Absorption 5-10 Fold
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, PhD Wants To 'Cure'
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David Made a Psoriasis-Treating Molecule More Potent Than Resveratrol
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David's Anti-Aging Work Faced Pushback from the Conventional Scientific Community
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David Sinclair's Anti-Aging Book, 'Lifespan,' Is a Paradigm-Breaking Masterpiece
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Having Grown Up in Australia, David Was Devastated By the Wildfires
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With His Anti-Aging Research, David Hopes to Save Billions from Being Wasted on Healthcare
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David Sinclair's Mission: Convince the FDA That Aging Is a Treatable Disease
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Your Genes Aren't Your Destiny; Lifestyle Accounts for 80% of Health in Old Age
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, PhD Wants To 'Cure'
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David's Father Is 80 and Runs Around Like He's 25
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Aging
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The Earlier You Invest in Longevity, the Better
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Doctors Treat Disease Without Thinking About the Root Cause
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If People Start Living Longer, Will Earth Become Overpopulated?
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Once People Start Living Longer, They'll Likely Have Kids Well Into Their Later Years
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They'll Come a Day When a 100-Year-Old Person Isn't Considered Old
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Easy Access to Information Makes Learning Easier Than Ever
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As Humans Begin Living to 150+, Will They Limit Risky Behaviors?
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There's No Point in Living to 100+ If You Don't Have a Sense of Purpose
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An Overarching Goal Helps You Push Through Life's Tough Times
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David's Vision for the Future: People Living to 250+ & Having Multiple Careers
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Living Well Into Our Hundreds Will Give People a Newfound Sense of Patience
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Aging
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50 Is the New 20 — Forget the Idea of Slowing Down in Old Age
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As People Start Living Longer, They'll Appreciate Elderly Wisdom More
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David Met Multiple Billionaires Because of His Successful Anti-Aging Book
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Why David Is Cautious About Recommending His Anti-Aging Supplement Routine
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To Live Longer, Eat Less Often — Stop Eating Three Meals Per Day
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, PhD Wants To 'Cure'
Aging
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To Increase Your Lifespan: Exercise, Fast, Sleep Well, Eat Mostly Plant-Based, & Be Social
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, PhD Wants To 'Cure'
Aging
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Why Eating a Predominantly Plant-Based Diet Is Optimal for Longevity
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, PhD Wants To 'Cure'
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The Carnivore Diet Accelerates Aging & Limits the Body's Defense Mechanisms
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, PhD Wants To 'Cure'
Aging
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With His Current Diet & Supplement Regimen, David Never Gets Sick
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, PhD Wants To 'Cure'
Aging
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Sirtuins, Fueled By NAD, Control the Body's Sleep/Wake Cycle
1:26 ·
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, PhD Wants To 'Cure'
Aging
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Why David Sinclair Supplements With NMN Instead of NR
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, PhD Wants To 'Cure'
Aging
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David Sinclair Takes Metformin to Reduce Disease Risk
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, PhD Wants To 'Cure'
Aging
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Metformin Enhances Mitochondrial Activity Through AMPK Activation
1:31 ·
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, PhD Wants To 'Cure'
Aging
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Metformin Doesn't Inhibit Muscle Hypertrophy Nearly as Much as People Think
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, PhD Wants To 'Cure'
Aging
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For David Sinclair, Metformin's Benefits Outweigh Its Risks
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, PhD Wants To 'Cure'
Aging
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David Sinclair's Mother Died from Lung Cancer
1:12 ·
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, PhD Wants To 'Cure'
Aging
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David Sinclair Is Excited About the Targeting Aging With Metformin (TAME) Trial
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, PhD Wants To 'Cure'
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Using Genetic Reprogramming Factors, David's Lab Restored Vision in Blind Mice
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, PhD Wants To 'Cure'
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In the Future, Will Gene Therapy Heal Every Possible Ailment?
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, PhD Wants To 'Cure'
Aging
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The Future of Civilization Rests on David Sinclair's Anti-Aging Research
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Connect With David Sinclair Online
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David & Rich Outro
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, PhD Wants To 'Cure'
Aging
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Rich Roll Outro
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Next Time on The Rich Roll Podcast: Cyrus Khambata, Ph.D. & Robby Barbaro
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