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David Sinclair & Matthew LaPlante Intro

0:29 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Although an Essential Nutrient, Excess Iron Accelerate Aging

2:17 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Excess Ferrous Iron Increases Free Radical Production, Damaging DNA & Driving Aging

2:07 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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10% of People Have the HFE Gene, Increasing Hemochromatosis Susceptibility

0:47 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Eating One Meal Per Day Helps David Activate Aging Defense Pathways

1:09 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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AD: Athletic Greens

1:06 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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AD: Levels

0:43 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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AD: InsideTracker

0:51 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Cynthia Kenyon Discovered DAF-2, an Insulin Receptor Gene, Controls Aging in Worms

5:05 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Modern Society Is Built on Comfort; Longevity Pathways Thrive Under Adversity

2:47 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Get Off Your Butt; Sedentary Lifestyles Promote Aging

2:16 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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50 Minutes of Exercise 3x/Week Reduces Cardiovascular Disease Risk By 30%

1:35 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Aim for 10,000 Steps/Day; Walking Post-Meal Reduces Blood Sugar Spikes

1:16 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Exercise Activates AMPK & Creates More Mitochondria

0:55 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Exercise-Induced Hypoxia Activates the HIF-1A Pathway & Generates Free Radicals

4:50 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Exercise Increases Glucose Sensitivity & Stimulates Blood Vessel Formation Via VEGF

3:54 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Measurable Via the Horvath or Proteomic Clock, Exercise Slows Aging

2:43 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Measure Your Biological Age; 80% of Your Future Health Is Modifiable

2:34 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Exercise Recommendations: >75 Minutes/Week & Do What You Enjoy

1:57 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Resting Heart Rate Is a Key Fitness Indicator; Aim for <50 BPM

0:29 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair Wears 3 Wearables: Ring, Wrist, & Chest

0:58 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair Has Been Measuring His Biological Age for 10 Years With InsideTracker

2:18 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Lifts Weights 3-4x/Week; It Maintains Muscle Mass & Testosterone Levels

2:53 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Senescent Cells Secrete Cancer-Causing Proteins; 12 Weeks of Exercise Reduces Levels

1:52 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David's Exercise Recommendations: Regular Movement, High-Intensity 75 Min./Week, & Weight Training

1:45 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Hyperbaric Oxygen Therapy Reverses Telomere Shortening & Improves Cognitive Performance

4:16 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Speculates the Cause of Hyperbaric Oxygen Therapy's Anti-Aging Benefits

1:54 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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60 90-Minute Hyperbaric Oxygen Treatment Sessions Reduces Senescent Cell Count

1:27 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Cold Therapy Activates Brown Fat, Boosting Metabolism & Protecting Against Disease

1:47 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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In Mice, Temperature-Induced Shivering Extends Lifespan Via UCP Genes

2:18 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair Recalls Trying Cryotherapy With Joe Rogan

0:56 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Why You Shouldn't Wait Until You're Old to Try Cold Therapy

0:33 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Cryotherapy Alternatives: Cold Showers or Sleeping Without Sheets

0:50 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Frequent Sauna Bathing Reduces Cardiovascular Disease By 20% in Men

3:27 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Vigorous Exercise, Sauna Bathing, & Cold Therapy Increase Endorphin Levels

0:48 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair's Recommended Sauna & Cold Therapy Protocol: More Is Better

1:57 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David & Matthew Outro

0:41 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair Outro

0:51 · Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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